An argument has raged back and forth as to whether the brain abnormalities in schizophrenia are either neurodegenerative or neurodevelopmental in origin (Weinberger and Marenco 2003). The neurodevelopmental view held ascendancy until several recent studies which have now provided evidence of progressive brain deterioration (DeLisi et al 1997; Vita et al 1997; Mathalon et al 2001; Thompson et al 2001; Cahn et al 2002; Ho, Andreasen, et al 2003; Sporn et al 2003).
neurodegenerative: resulting in or characterized by degeneration of the nervous system, especially the neurons in the brain.
neurodevelopmental: disorders are disabilities in the functioning of the brain that affect a child’s behaviour, memory or ability to learn e.g. mental retardation, dyslexia, attention deficit hyperactivity disorder (ADHD), learning deficits and autism.